DETAILED NOTES ON LDN-27219 CHEMICAL STRUCTURE

A single specifically fascinating compound is LDN-27219. Whilst most tTG inhibitors are made to bind to the protein crosslinking Energetic website, LDN-27219 instead binds into the nucleotide binding pocket of your enzyme even though it is actually in its shut-state conformation, and stabilizes that conformation to forestall crosslinking activity.s